Chaque enregistrement correpond à un patient qui a réalisé une ponction lombère (LCR). Une LCR n’étant pas réalisée pour des raisons mineurs, tous les patients de la BDD ont présentés des problèmes cognitifs.
L’objectif de l’étude est d’analyser l’association entre différents biomarqueurs sanguins et les protéines Abeta et tau, marqueurs de la maladie d’Alzheimer.
## [1] "Nombre d'observations : 1804"
## [1] "Nombre de variables : 180"
## $breaks
## [1] 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95
##
## $counts
## [1] 1 0 1 2 3 12 38 105 170 237 382 364 289 159 40 1
##
## $density
## [1] 0.0001108647 0.0000000000 0.0001108647 0.0002217295 0.0003325942
## [6] 0.0013303769 0.0042128603 0.0116407982 0.0188470067 0.0262749446
## [11] 0.0423503326 0.0403547672 0.0320399113 0.0176274945 0.0044345898
## [16] 0.0001108647
##
## $mids
## [1] 17.5 22.5 27.5 32.5 37.5 42.5 47.5 52.5 57.5 62.5 67.5 72.5 77.5 82.5 87.5
## [16] 92.5
##
## $xname
## [1] "d"
##
## $equidist
## [1] TRUE
##
## attr(,"class")
## [1] "histogram"
1 = non scolarisé
2 = primaire sans diplôme
3 = certificat d’études
4 = secondaire (collège/CAP/brevet)
5 = secondaire (BEP/lycée)
6 = baccalauréat
7 = études supérieures
8 = non renseigné
## [1] "Jamais marié" "Divorcé" "Marié / en couple"
## [4] "Veuf"
## [1] "Insuffisance pondérale" "Corpulence normale"
## [3] "Obésité modérée" "Obésité morbide ou massive"
## [5] "Obésité sévère" "Surpoids"
data2 = clean_names(data2)
L = c("trt1","trt2","trt3","trt4","trt5","trt6","trt7","trt8","trt9","trt10",
"trt11","trt12","trt13","trt14","trt15","trt16","trt17","trt18","trt19","trt20")
trt_total = data.frame(x = data2$trt1)
for (i in 2:length(L)){
b = data.frame(x = data2[,L[i]])
trt_total = rbind(trt_total,b)
}
trt_total = trt_total %>%
mutate(x = tolower(x))%>%
filter(x != c(""))
### Masque
for (i in 1:nrow(trt_total)){
trt_total[i,1] = gsub("y","i", trt_total[i,1])
trt_total[i,1] = gsub("ll","l", trt_total[i,1])
trt_total[i,1] = gsub("ff","f", trt_total[i,1])
trt_total[i,1] = gsub("ph","f", trt_total[i,1])
trt_total[i,1] = gsub("h","", trt_total[i,1])
trt_total[i,1] = gsub("pp","p", trt_total[i,1])
trt_total[i,1] = gsub(",","", trt_total[i,1])
trt_total[i,1] = gsub("_","", trt_total[i,1])
#trt_total[i,1] = gsub(".","", trt_total[i,1])
trt_total[i,1] = gsub("0","", trt_total[i,1])
trt_total[i,1] = gsub("1","", trt_total[i,1])
trt_total[i,1] = gsub("2","", trt_total[i,1])
trt_total[i,1] = gsub("3","", trt_total[i,1])
trt_total[i,1] = gsub("4","", trt_total[i,1])
trt_total[i,1] = gsub("5","", trt_total[i,1])
trt_total[i,1] = gsub("6","", trt_total[i,1])
trt_total[i,1] = gsub("7","", trt_total[i,1])
trt_total[i,1] = gsub("8","", trt_total[i,1])
trt_total[i,1] = gsub("9","", trt_total[i,1])
if (length(grep(" ", trt_total[i,1], ignore.case = TRUE)) > 0){
pos = regexpr(pattern=" ",trt_total[i,1],fixed=TRUE)[1]
trt_total[i,1] = substr(trt_total[i,1],1,pos-1)
}
trt_total[i,1] = gsub(" ","", trt_total[i,1])
if(substr(trt_total[i,1],nchar(trt_total[i,1]),nchar(trt_total[i,1])) == "e"){
trt_total[i,1] = gsub('.{1}$', '', trt_total[i,1])
}
}
medi_total = c(medi_chol,medi_diabete,medi_HTA,medi_antidouleur,medi_anxiete,medi_cv,medi_depression,medi_ma,medi_parkinson,medi_sommeil,medi_trouble,medi_vitamines)
trt_total = trt_total %>%
mutate(x = tolower(x))%>%
filter(x != c(""),!x %in% medi_total)
dat_test <- data.frame(x = trt_total)
med_nb = dat_test %>%
mutate(x = tolower(x)) %>%
filter(dat_test != "",!x %in% medi_total)%>%
gather(value = "Modalités") %>%
group_by(Modalités) %>%
summarise(n = n()) %>% arrange(desc(n))
## Warning: Using one column matrices in `filter()` was deprecated in dplyr 1.1.0.
## ℹ Please use one dimensional logical vectors instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
med_nb = as.data.frame(med_nb)
med_nb
#write_xlsx(med_nb,"//172.27.137.244/g_boilay/alternance/export/med.xlsx")
#write.csv(med_nb,"//172.27.137.244/g_boilay/alternance/export/med.csv")
1 = MA
2 = MCI amnésique
3 = MCI autre
4= Démence mixte
5 = Démence vasculaire
6 = DFT
7 = Lewy
8 = Atrophie corticale postérieure
9 = Démence alcoolique
10 = Aphasie progressive primaire
11 = Trouble psychiatrique
12 = VIH
13 = NSP
14 = Autre
Standardisation du logarithme de la variable multipliée par -1 en prenant en compte les différentes périodes
Standardisation du logarithme de la variable multipliée par -1 en prenant en compte les différentes périodes
Standardisation du logarithme de la variable en prenant en compte les différentes périodes
Standardisation du logarithme de la variable en prenant en compte les différentes périodes
## Warning: Unknown or uninitialised column: `cholesterol_total.reg`.
## Warning: Unknown or uninitialised column: `cholesterol_hdl.reg`.
## Warning: Unknown or uninitialised column: `glucose_jeun.reg`.
## Warning: Unknown or uninitialised column: `folates.reg`.
## Warning: Unknown or uninitialised column: `vitamine_b12.reg`.
## Warning: Unknown or uninitialised column: `vitamine_d.reg`.
## Warning: Unknown or uninitialised column: `proteines.reg`.
## Warning: Unknown or uninitialised column: `tsh.reg`.
## Warning: Unknown or uninitialised column: `uree.reg`.
## Warning: Unknown or uninitialised column: `creatinine.reg`.
## Warning: Unknown or uninitialised column: `calcium.reg`.
## integer(0)
| abeta42 faible (N=502) | abeta42 normal (N=474) | Total (N=976) | p value | |
|---|---|---|---|---|
| Age | < 0.001 | |||
| - Mean (SD) | 71.259 (8.141) | 67.977 (9.341) | 69.665 (8.893) | |
| - Range | 47.000 - 89.000 | 42.000 - 89.000 | 42.000 - 89.000 | |
| Sexe | 0.064 | |||
| - Femme | 287 (57.2%) | 243 (51.3%) | 530 (54.3%) | |
| - Homme | 215 (42.8%) | 231 (48.7%) | 446 (45.7%) | |
| Glucose | 0.782 | |||
| - Mean (SD) | 5.739 (1.546) | 5.769 (1.828) | 5.754 (1.688) | |
| - Range | 0.720 - 18.500 | 0.920 - 24.500 | 0.720 - 24.500 | |
| Triglycerides | 0.709 | |||
| - Mean (SD) | 0.948 (0.333) | 0.956 (0.346) | 0.951 (0.339) | |
| - Range | 0.380 - 1.970 | 0.150 - 1.970 | 0.150 - 1.970 | |
| Cholesterol | 0.002 | |||
| - Mean (SD) | 2.167 (0.509) | 2.064 (0.507) | 2.117 (0.510) | |
| - Range | 1.030 - 6.640 | 0.820 - 5.900 | 0.820 - 6.640 | |
| Cholesterol hdl | 0.105 | |||
| - Mean (SD) | 0.601 (0.167) | 0.584 (0.152) | 0.593 (0.160) | |
| - Range | 0.210 - 1.590 | 0.270 - 1.380 | 0.210 - 1.590 | |
| Cholesterol ldl | < 0.001 | |||
| - Mean (SD) | 1.370 (0.404) | 1.269 (0.381) | 1.321 (0.396) | |
| - Range | 0.360 - 2.970 | 0.200 - 2.630 | 0.200 - 2.970 | |
| Présence E4 | < 0.001 | |||
| - 0 | 195 (38.8%) | 345 (72.8%) | 540 (55.3%) | |
| - 1 | 230 (45.8%) | 122 (25.7%) | 352 (36.1%) | |
| - 2 | 77 (15.3%) | 7 (1.5%) | 84 (8.6%) | |
| MMSE | < 0.001 | |||
| - Mean (SD) | 21.106 (5.435) | 23.951 (4.458) | 22.488 (5.181) | |
| - Range | 4.000 - 30.000 | 5.000 - 30.000 | 4.000 - 30.000 | |
| Traitement cholesterol | 0.215 | |||
| - 0 | 420 (83.7%) | 410 (86.5%) | 830 (85.0%) | |
| - 1 | 82 (16.3%) | 64 (13.5%) | 146 (15.0%) | |
| Traitement Diabete | 0.170 | |||
| - 0 | 472 (94.0%) | 435 (91.8%) | 907 (92.9%) | |
| - 1 | 30 (6.0%) | 39 (8.2%) | 69 (7.1%) | |
| Niveau d’étude | 0.126 | |||
| - N-Miss | 31 | 35 | 66 | |
| - études supérieurs | 174 (36.9%) | 166 (37.8%) | 340 (37.4%) | |
| - niveau études intermédiaires | 159 (33.8%) | 169 (38.5%) | 328 (36.0%) | |
| - niveau études mineurs | 138 (29.3%) | 104 (23.7%) | 242 (26.6%) |
## [1] "N = 1009"
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.26 | 1.10, 1.44 | <0.001 |
| age | 1.59 | 1.37, 1.85 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.25 | 1.08, 1.44 | 0.002 |
| age | 1.59 | 1.37, 1.84 | <0.001 |
| sexe | 1.12 | 0.86, 1.47 | 0.4 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.05 | 0.78, 1.42 | 0.7 |
| niveau études mineurs | 1.28 | 0.92, 1.77 | 0.14 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.18 | 1.02, 1.37 | 0.028 |
| age | 1.64 | 1.40, 1.92 | <0.001 |
| sexe | 1.20 | 0.90, 1.59 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.94 | 0.68, 1.29 | 0.7 |
| niveau études mineurs | 1.21 | 0.86, 1.71 | 0.3 |
| apoe.reg2 | 3.39 | 2.70, 4.29 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.19 | 1.02, 1.38 | 0.025 |
| age | 1.64 | 1.40, 1.94 | <0.001 |
| sexe | 1.13 | 0.84, 1.51 | 0.4 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.11 | 0.2 |
| niveau études mineurs | 0.75 | 0.51, 1.10 | 0.14 |
| apoe.reg2 | 3.21 | 2.55, 4.08 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.19 | 1.03, 1.39 | 0.022 |
| age | 1.63 | 1.39, 1.93 | <0.001 |
| sexe | 1.12 | 0.84, 1.51 | 0.4 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.11 | 0.2 |
| niveau études mineurs | 0.74 | 0.51, 1.09 | 0.13 |
| apoe.reg2 | 3.21 | 2.55, 4.08 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| ch | 1.11 | 0.75, 1.65 | 0.6 |
| dia | 1.02 | 0.60, 1.71 | >0.9 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.18 | 1.01, 1.37 | 0.039 |
| age | 1.60 | 1.36, 1.89 | <0.001 |
| sexe | 1.08 | 0.80, 1.46 | 0.6 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.83 | 0.60, 1.16 | 0.3 |
| niveau études mineurs | 0.79 | 0.54, 1.17 | 0.2 |
| apoe.reg2 | 3.18 | 2.52, 4.04 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| ch | 1.13 | 0.76, 1.68 | 0.5 |
| dia | 1.08 | 0.64, 1.83 | 0.8 |
| imc | 0.96 | 0.92, 0.99 | 0.007 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| cholesterol_total | 1.26 | 1.10, 1.44 | <0.001 | 1.25 | 1.08, 1.44 | 0.002 | 1.18 | 1.02, 1.37 | 0.028 | 1.19 | 1.02, 1.38 | 0.025 | 1.19 | 1.03, 1.39 | 0.022 | 1.18 | 1.01, 1.37 | 0.039 |
| age | 1.59 | 1.37, 1.85 | <0.001 | 1.59 | 1.37, 1.84 | <0.001 | 1.64 | 1.40, 1.92 | <0.001 | 1.64 | 1.40, 1.94 | <0.001 | 1.63 | 1.39, 1.93 | <0.001 | 1.60 | 1.36, 1.89 | <0.001 |
| sexe | 1.12 | 0.86, 1.47 | 0.4 | 1.20 | 0.90, 1.59 | 0.2 | 1.13 | 0.84, 1.51 | 0.4 | 1.12 | 0.84, 1.51 | 0.4 | 1.08 | 0.80, 1.46 | 0.6 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.05 | 0.78, 1.42 | 0.7 | 0.94 | 0.68, 1.29 | 0.7 | 0.80 | 0.58, 1.11 | 0.2 | 0.80 | 0.58, 1.11 | 0.2 | 0.83 | 0.60, 1.16 | 0.3 | |||
| niveau études mineurs | 1.28 | 0.92, 1.77 | 0.14 | 1.21 | 0.86, 1.71 | 0.3 | 0.75 | 0.51, 1.10 | 0.14 | 0.74 | 0.51, 1.09 | 0.13 | 0.79 | 0.54, 1.17 | 0.2 | |||
| apoe.reg2 | 3.39 | 2.70, 4.29 | <0.001 | 3.21 | 2.55, 4.08 | <0.001 | 3.21 | 2.55, 4.08 | <0.001 | 3.18 | 2.52, 4.04 | <0.001 | ||||||
| mmse | 0.90 | 0.87, 0.93 | <0.001 | 0.90 | 0.87, 0.93 | <0.001 | 0.90 | 0.87, 0.93 | <0.001 | |||||||||
| ch | 1.11 | 0.75, 1.65 | 0.6 | 1.13 | 0.76, 1.68 | 0.5 | ||||||||||||
| dia | 1.02 | 0.60, 1.71 | >0.9 | 1.08 | 0.64, 1.83 | 0.8 | ||||||||||||
| imc | 0.96 | 0.92, 0.99 | 0.007 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1038"
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.84, 1.07 | 0.4 |
| age | 1.55 | 1.34, 1.79 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.97 | 0.85, 1.10 | 0.6 |
| age | 1.56 | 1.35, 1.80 | <0.001 |
| sexe | 1.30 | 1.00, 1.68 | 0.049 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.76, 1.35 | >0.9 |
| niveau études mineurs | 1.22 | 0.89, 1.68 | 0.2 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.83, 1.08 | 0.4 |
| age | 1.60 | 1.38, 1.87 | <0.001 |
| sexe | 1.32 | 1.00, 1.73 | 0.049 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.92 | 0.68, 1.26 | 0.6 |
| niveau études mineurs | 1.17 | 0.84, 1.65 | 0.4 |
| apoe.reg2 | 3.34 | 2.67, 4.20 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.83, 1.09 | 0.4 |
| age | 1.61 | 1.37, 1.89 | <0.001 |
| sexe | 1.25 | 0.94, 1.65 | 0.13 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.10 | 0.2 |
| niveau études mineurs | 0.69 | 0.47, 1.00 | 0.052 |
| apoe.reg2 | 3.22 | 2.57, 4.08 | <0.001 |
| mmse | 0.89 | 0.86, 0.92 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.94 | 0.81, 1.10 | 0.5 |
| age | 1.60 | 1.36, 1.88 | <0.001 |
| sexe | 1.25 | 0.94, 1.65 | 0.13 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.79 | 0.58, 1.10 | 0.2 |
| niveau études mineurs | 0.68 | 0.46, 1.00 | 0.049 |
| apoe.reg2 | 3.22 | 2.56, 4.08 | <0.001 |
| mmse | 0.89 | 0.86, 0.92 | <0.001 |
| ch | 1.06 | 0.73, 1.56 | 0.8 |
| dia | 1.03 | 0.59, 1.80 | >0.9 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.98 | 0.84, 1.15 | 0.8 |
| age | 1.56 | 1.33, 1.84 | <0.001 |
| sexe | 1.21 | 0.91, 1.60 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.83 | 0.60, 1.14 | 0.2 |
| niveau études mineurs | 0.73 | 0.50, 1.08 | 0.11 |
| apoe.reg2 | 3.15 | 2.51, 4.00 | <0.001 |
| mmse | 0.89 | 0.86, 0.92 | <0.001 |
| ch | 1.10 | 0.75, 1.62 | 0.6 |
| dia | 1.04 | 0.59, 1.83 | 0.9 |
| imc | 0.95 | 0.92, 0.99 | 0.005 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| glucose_jeun | 0.95 | 0.84, 1.07 | 0.4 | 0.97 | 0.85, 1.10 | 0.6 | 0.95 | 0.83, 1.08 | 0.4 | 0.95 | 0.83, 1.09 | 0.4 | 0.94 | 0.81, 1.10 | 0.5 | 0.98 | 0.84, 1.15 | 0.8 |
| age | 1.55 | 1.34, 1.79 | <0.001 | 1.56 | 1.35, 1.80 | <0.001 | 1.60 | 1.38, 1.87 | <0.001 | 1.61 | 1.37, 1.89 | <0.001 | 1.60 | 1.36, 1.88 | <0.001 | 1.56 | 1.33, 1.84 | <0.001 |
| sexe | 1.30 | 1.00, 1.68 | 0.049 | 1.32 | 1.00, 1.73 | 0.049 | 1.25 | 0.94, 1.65 | 0.13 | 1.25 | 0.94, 1.65 | 0.13 | 1.21 | 0.91, 1.60 | 0.2 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.01 | 0.76, 1.35 | >0.9 | 0.92 | 0.68, 1.26 | 0.6 | 0.80 | 0.58, 1.10 | 0.2 | 0.79 | 0.58, 1.10 | 0.2 | 0.83 | 0.60, 1.14 | 0.2 | |||
| niveau études mineurs | 1.22 | 0.89, 1.68 | 0.2 | 1.17 | 0.84, 1.65 | 0.4 | 0.69 | 0.47, 1.00 | 0.052 | 0.68 | 0.46, 1.00 | 0.049 | 0.73 | 0.50, 1.08 | 0.11 | |||
| apoe.reg2 | 3.34 | 2.67, 4.20 | <0.001 | 3.22 | 2.57, 4.08 | <0.001 | 3.22 | 2.56, 4.08 | <0.001 | 3.15 | 2.51, 4.00 | <0.001 | ||||||
| mmse | 0.89 | 0.86, 0.92 | <0.001 | 0.89 | 0.86, 0.92 | <0.001 | 0.89 | 0.86, 0.92 | <0.001 | |||||||||
| ch | 1.06 | 0.73, 1.56 | 0.8 | 1.10 | 0.75, 1.62 | 0.6 | ||||||||||||
| dia | 1.03 | 0.59, 1.80 | >0.9 | 1.04 | 0.59, 1.83 | 0.9 | ||||||||||||
| imc | 0.95 | 0.92, 0.99 | 0.005 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1009"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.10 | 0.04, 0.16 | 0.002 |
| age | 0.22 | 0.16, 0.29 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.11 | 0.05, 0.17 | <0.001 |
| age | 0.22 | 0.15, 0.29 | <0.001 |
| sexe | -0.07 | -0.19, 0.06 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.00 | -0.14, 0.14 | >0.9 |
| niveau études mineurs | 0.09 | -0.07, 0.24 | 0.3 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.020 |
| age | 0.21 | 0.15, 0.27 | <0.001 |
| sexe | -0.04 | -0.16, 0.08 | 0.5 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.06 | -0.19, 0.07 | 0.4 |
| niveau études mineurs | 0.05 | -0.09, 0.19 | 0.5 |
| apoe.reg2 | 0.64 | 0.55, 0.72 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.02, 0.13 | 0.011 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.07 | -0.18, 0.04 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.034 |
| niveau études mineurs | -0.19 | -0.34, -0.05 | 0.009 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.02, 0.13 | 0.012 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.07 | -0.18, 0.04 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.035 |
| niveau études mineurs | -0.19 | -0.34, -0.04 | 0.010 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | 0.00 | -0.15, 0.15 | >0.9 |
| dia | -0.01 | -0.22, 0.19 | 0.9 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.02, 0.13 | 0.013 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.08 | -0.19, 0.03 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.25, 0.00 | 0.046 |
| niveau études mineurs | -0.18 | -0.33, -0.04 | 0.014 |
| apoe.reg2 | 0.58 | 0.50, 0.66 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | 0.00 | -0.15, 0.15 | >0.9 |
| dia | -0.01 | -0.21, 0.19 | >0.9 |
| imc | 0.00 | -0.01, 0.00 | 0.10 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.10 | 0.04, 0.16 | 0.002 | 0.11 | 0.05, 0.17 | <0.001 | 0.07 | 0.01, 0.13 | 0.020 | 0.07 | 0.02, 0.13 | 0.011 | 0.07 | 0.02, 0.13 | 0.012 | 0.07 | 0.02, 0.13 | 0.013 |
| age | 0.22 | 0.16, 0.29 | <0.001 | 0.22 | 0.15, 0.29 | <0.001 | 0.21 | 0.15, 0.27 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.07 | -0.19, 0.06 | 0.3 | -0.04 | -0.16, 0.08 | 0.5 | -0.07 | -0.18, 0.04 | 0.2 | -0.07 | -0.18, 0.04 | 0.2 | -0.08 | -0.19, 0.03 | 0.2 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.00 | -0.14, 0.14 | >0.9 | -0.06 | -0.19, 0.07 | 0.4 | -0.13 | -0.26, -0.01 | 0.034 | -0.13 | -0.26, -0.01 | 0.035 | -0.13 | -0.25, 0.00 | 0.046 | |||
| niveau études mineurs | 0.09 | -0.07, 0.24 | 0.3 | 0.05 | -0.09, 0.19 | 0.5 | -0.19 | -0.34, -0.05 | 0.009 | -0.19 | -0.34, -0.04 | 0.010 | -0.18 | -0.33, -0.04 | 0.014 | |||
| apoe.reg2 | 0.64 | 0.55, 0.72 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.58 | 0.50, 0.66 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | |||||||||
| ch | 0.00 | -0.15, 0.15 | >0.9 | 0.00 | -0.15, 0.15 | >0.9 | ||||||||||||
| dia | -0.01 | -0.22, 0.19 | 0.9 | -0.01 | -0.21, 0.19 | >0.9 | ||||||||||||
| imc | 0.00 | -0.01, 0.00 | 0.10 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1038"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.21 | 0.14, 0.28 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.21 | 0.14, 0.27 | <0.001 |
| sexe | -0.02 | -0.14, 0.10 | 0.8 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.16, 0.12 | 0.8 |
| niveau études mineurs | 0.05 | -0.11, 0.20 | 0.5 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.081 |
| age | 0.20 | 0.14, 0.26 | <0.001 |
| sexe | -0.03 | -0.14, 0.09 | 0.6 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.06 | -0.19, 0.06 | 0.3 |
| niveau études mineurs | 0.02 | -0.12, 0.16 | 0.8 |
| apoe.reg2 | 0.63 | 0.55, 0.72 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.10, 0.01 | 0.088 |
| age | 0.19 | 0.13, 0.24 | <0.001 |
| sexe | -0.06 | -0.16, 0.05 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.035 |
| niveau études mineurs | -0.24 | -0.39, -0.10 | 0.001 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.11 |
| age | 0.19 | 0.13, 0.25 | <0.001 |
| sexe | -0.06 | -0.16, 0.05 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.26, -0.01 | 0.035 |
| niveau études mineurs | -0.24 | -0.39, -0.10 | 0.001 |
| apoe.reg2 | 0.59 | 0.50, 0.67 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | -0.01 | -0.16, 0.14 | >0.9 |
| dia | 0.02 | -0.20, 0.23 | 0.9 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.15 |
| age | 0.18 | 0.12, 0.24 | <0.001 |
| sexe | -0.06 | -0.17, 0.05 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.13 | -0.25, 0.00 | 0.046 |
| niveau études mineurs | -0.24 | -0.38, -0.09 | 0.002 |
| apoe.reg2 | 0.58 | 0.50, 0.66 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | -0.01 | -0.15, 0.14 | >0.9 |
| dia | 0.02 | -0.20, 0.23 | 0.9 |
| imc | -0.01 | -0.01, 0.00 | 0.075 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 | -0.04 | -0.10, 0.02 | 0.2 | -0.05 | -0.11, 0.01 | 0.081 | -0.05 | -0.10, 0.01 | 0.088 | -0.05 | -0.11, 0.01 | 0.11 | -0.04 | -0.10, 0.02 | 0.15 |
| age | 0.21 | 0.14, 0.28 | <0.001 | 0.21 | 0.14, 0.27 | <0.001 | 0.20 | 0.14, 0.26 | <0.001 | 0.19 | 0.13, 0.24 | <0.001 | 0.19 | 0.13, 0.25 | <0.001 | 0.18 | 0.12, 0.24 | <0.001 |
| sexe | -0.02 | -0.14, 0.10 | 0.8 | -0.03 | -0.14, 0.09 | 0.6 | -0.06 | -0.16, 0.05 | 0.3 | -0.06 | -0.16, 0.05 | 0.3 | -0.06 | -0.17, 0.05 | 0.3 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | -0.02 | -0.16, 0.12 | 0.8 | -0.06 | -0.19, 0.06 | 0.3 | -0.13 | -0.26, -0.01 | 0.035 | -0.13 | -0.26, -0.01 | 0.035 | -0.13 | -0.25, 0.00 | 0.046 | |||
| niveau études mineurs | 0.05 | -0.11, 0.20 | 0.5 | 0.02 | -0.12, 0.16 | 0.8 | -0.24 | -0.39, -0.10 | 0.001 | -0.24 | -0.39, -0.10 | 0.001 | -0.24 | -0.38, -0.09 | 0.002 | |||
| apoe.reg2 | 0.63 | 0.55, 0.72 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.59 | 0.50, 0.67 | <0.001 | 0.58 | 0.50, 0.66 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | |||||||||
| ch | -0.01 | -0.16, 0.14 | >0.9 | -0.01 | -0.15, 0.14 | >0.9 | ||||||||||||
| dia | 0.02 | -0.20, 0.23 | 0.9 | 0.02 | -0.20, 0.23 | 0.9 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.075 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1009"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.08 | 0.02, 0.14 | 0.011 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.00, 0.14 | 0.040 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| sexe | 0.08 | -0.05, 0.22 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.16, 0.13 | 0.8 |
| niveau études mineurs | 0.01 | -0.15, 0.17 | 0.9 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.3 |
| age | 0.29 | 0.23, 0.36 | <0.001 |
| sexe | 0.10 | -0.03, 0.22 | 0.12 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.05 | -0.18, 0.09 | 0.5 |
| niveau études mineurs | 0.00 | -0.15, 0.15 | >0.9 |
| apoe.reg2 | 0.54 | 0.45, 0.63 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.3 |
| age | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.09 | -0.04, 0.21 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.09 | -0.23, 0.05 | 0.2 |
| niveau études mineurs | -0.12 | -0.28, 0.04 | 0.14 |
| apoe.reg2 | 0.51 | 0.42, 0.60 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.08 | -0.04, 0.20 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.09 | -0.22, 0.05 | 0.2 |
| niveau études mineurs | -0.11 | -0.27, 0.05 | 0.2 |
| apoe.reg2 | 0.51 | 0.42, 0.60 | <0.001 |
| mmse | -0.02 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.22 | -0.45, 0.01 | 0.062 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.28 | 0.21, 0.35 | <0.001 |
| sexe | 0.07 | -0.06, 0.19 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.07 | -0.21, 0.06 | 0.3 |
| niveau études mineurs | -0.09 | -0.25, 0.07 | 0.3 |
| apoe.reg2 | 0.50 | 0.41, 0.59 | <0.001 |
| mmse | -0.02 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.21 | -0.44, 0.02 | 0.077 |
| imc | -0.01 | -0.01, 0.00 | 0.007 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.08 | 0.02, 0.14 | 0.011 | 0.07 | 0.00, 0.14 | 0.040 | 0.03 | -0.03, 0.09 | 0.3 | 0.03 | -0.03, 0.09 | 0.3 | 0.03 | -0.03, 0.09 | 0.4 | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.30 | 0.23, 0.37 | <0.001 | 0.30 | 0.23, 0.37 | <0.001 | 0.29 | 0.23, 0.36 | <0.001 | 0.29 | 0.22, 0.36 | <0.001 | 0.29 | 0.22, 0.36 | <0.001 | 0.28 | 0.21, 0.35 | <0.001 |
| sexe | 0.08 | -0.05, 0.22 | 0.2 | 0.10 | -0.03, 0.22 | 0.12 | 0.09 | -0.04, 0.21 | 0.2 | 0.08 | -0.04, 0.20 | 0.2 | 0.07 | -0.06, 0.19 | 0.3 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | -0.02 | -0.16, 0.13 | 0.8 | -0.05 | -0.18, 0.09 | 0.5 | -0.09 | -0.23, 0.05 | 0.2 | -0.09 | -0.22, 0.05 | 0.2 | -0.07 | -0.21, 0.06 | 0.3 | |||
| niveau études mineurs | 0.01 | -0.15, 0.17 | 0.9 | 0.00 | -0.15, 0.15 | >0.9 | -0.12 | -0.28, 0.04 | 0.14 | -0.11 | -0.27, 0.05 | 0.2 | -0.09 | -0.25, 0.07 | 0.3 | |||
| apoe.reg2 | 0.54 | 0.45, 0.63 | <0.001 | 0.51 | 0.42, 0.60 | <0.001 | 0.51 | 0.42, 0.60 | <0.001 | 0.50 | 0.41, 0.59 | <0.001 | ||||||
| mmse | -0.03 | -0.04, -0.01 | <0.001 | -0.02 | -0.04, -0.01 | <0.001 | -0.02 | -0.04, -0.01 | <0.001 | |||||||||
| ch | 0.03 | -0.13, 0.20 | 0.7 | 0.03 | -0.13, 0.20 | 0.7 | ||||||||||||
| dia | -0.22 | -0.45, 0.01 | 0.062 | -0.21 | -0.44, 0.02 | 0.077 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.007 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 885"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.12 |
| age | 0.31 | 0.24, 0.38 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.11, 0.02 | 0.2 |
| age | 0.31 | 0.24, 0.38 | <0.001 |
| sexe | 0.11 | -0.02, 0.24 | 0.11 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.17, 0.13 | 0.8 |
| niveau études mineurs | 0.00 | -0.16, 0.17 | >0.9 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.13 |
| age | 0.31 | 0.24, 0.38 | <0.001 |
| sexe | 0.09 | -0.03, 0.22 | 0.13 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.04 | -0.17, 0.10 | 0.6 |
| niveau études mineurs | 0.01 | -0.14, 0.16 | 0.9 |
| apoe.reg2 | 0.52 | 0.43, 0.62 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.02 | 0.14 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| sexe | 0.08 | -0.04, 0.21 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.07 | -0.21, 0.07 | 0.3 |
| niveau études mineurs | -0.11 | -0.27, 0.05 | 0.2 |
| apoe.reg2 | 0.50 | 0.41, 0.59 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.10, 0.03 | 0.3 |
| age | 0.30 | 0.23, 0.37 | <0.001 |
| sexe | 0.08 | -0.04, 0.20 | 0.2 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.07 | -0.21, 0.07 | 0.3 |
| niveau études mineurs | -0.11 | -0.27, 0.06 | 0.2 |
| apoe.reg2 | 0.49 | 0.40, 0.59 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.14 | -0.38, 0.11 | 0.3 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.07 | -0.05, 0.19 | 0.3 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.06 | -0.20, 0.08 | 0.4 |
| niveau études mineurs | -0.09 | -0.26, 0.07 | 0.3 |
| apoe.reg2 | 0.49 | 0.39, 0.58 | <0.001 |
| mmse | -0.03 | -0.04, -0.01 | <0.001 |
| ch | 0.03 | -0.13, 0.20 | 0.7 |
| dia | -0.14 | -0.38, 0.11 | 0.3 |
| imc | -0.01 | -0.01, 0.00 | 0.007 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.12 | -0.04 | -0.11, 0.02 | 0.2 | -0.05 | -0.11, 0.01 | 0.13 | -0.05 | -0.11, 0.02 | 0.14 | -0.03 | -0.10, 0.03 | 0.3 | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.31 | 0.24, 0.38 | <0.001 | 0.31 | 0.24, 0.38 | <0.001 | 0.31 | 0.24, 0.38 | <0.001 | 0.30 | 0.23, 0.37 | <0.001 | 0.30 | 0.23, 0.37 | <0.001 | 0.29 | 0.22, 0.36 | <0.001 |
| sexe | 0.11 | -0.02, 0.24 | 0.11 | 0.09 | -0.03, 0.22 | 0.13 | 0.08 | -0.04, 0.21 | 0.2 | 0.08 | -0.04, 0.20 | 0.2 | 0.07 | -0.05, 0.19 | 0.3 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | -0.02 | -0.17, 0.13 | 0.8 | -0.04 | -0.17, 0.10 | 0.6 | -0.07 | -0.21, 0.07 | 0.3 | -0.07 | -0.21, 0.07 | 0.3 | -0.06 | -0.20, 0.08 | 0.4 | |||
| niveau études mineurs | 0.00 | -0.16, 0.17 | >0.9 | 0.01 | -0.14, 0.16 | 0.9 | -0.11 | -0.27, 0.05 | 0.2 | -0.11 | -0.27, 0.06 | 0.2 | -0.09 | -0.26, 0.07 | 0.3 | |||
| apoe.reg2 | 0.52 | 0.43, 0.62 | <0.001 | 0.50 | 0.41, 0.59 | <0.001 | 0.49 | 0.40, 0.59 | <0.001 | 0.49 | 0.39, 0.58 | <0.001 | ||||||
| mmse | -0.03 | -0.04, -0.01 | <0.001 | -0.03 | -0.04, -0.01 | <0.001 | -0.03 | -0.04, -0.01 | <0.001 | |||||||||
| ch | 0.03 | -0.13, 0.20 | 0.7 | 0.03 | -0.13, 0.20 | 0.7 | ||||||||||||
| dia | -0.14 | -0.38, 0.11 | 0.3 | -0.14 | -0.38, 0.11 | 0.3 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.007 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
| tau elevé (N=543) | tau normal (N=433) | Total (N=976) | p value | |
|---|---|---|---|---|
| Age | < 0.001 | |||
| - Mean (SD) | 71.516 (8.098) | 67.344 (9.301) | 69.665 (8.893) | |
| - Range | 49.000 - 89.000 | 42.000 - 88.000 | 42.000 - 89.000 | |
| Sexe | < 0.001 | |||
| - Femme | 322 (59.3%) | 208 (48.0%) | 530 (54.3%) | |
| - Homme | 221 (40.7%) | 225 (52.0%) | 446 (45.7%) | |
| Glucose | 0.732 | |||
| - Mean (SD) | 5.770 (1.723) | 5.733 (1.645) | 5.754 (1.688) | |
| - Range | 0.920 - 20.900 | 0.720 - 24.500 | 0.720 - 24.500 | |
| Triglycerides | 0.021 | |||
| - Mean (SD) | 0.929 (0.328) | 0.980 (0.351) | 0.951 (0.339) | |
| - Range | 0.340 - 1.970 | 0.150 - 1.970 | 0.150 - 1.970 | |
| Cholesterol | 0.061 | |||
| - Mean (SD) | 2.144 (0.510) | 2.083 (0.510) | 2.117 (0.510) | |
| - Range | 0.820 - 6.640 | 0.970 - 5.900 | 0.820 - 6.640 | |
| Cholesterol hdl | < 0.001 | |||
| - Mean (SD) | 0.610 (0.164) | 0.572 (0.153) | 0.593 (0.160) | |
| - Range | 0.210 - 1.100 | 0.220 - 1.590 | 0.210 - 1.590 | |
| Cholesterol ldl | 0.062 | |||
| - Mean (SD) | 1.342 (0.408) | 1.294 (0.379) | 1.321 (0.396) | |
| - Range | 0.200 - 2.730 | 0.480 - 2.970 | 0.200 - 2.970 | |
| Présence E4 | < 0.001 | |||
| - 0 | 240 (44.2%) | 300 (69.3%) | 540 (55.3%) | |
| - 1 | 242 (44.6%) | 110 (25.4%) | 352 (36.1%) | |
| - 2 | 61 (11.2%) | 23 (5.3%) | 84 (8.6%) | |
| MMSE | < 0.001 | |||
| - Mean (SD) | 21.297 (5.439) | 23.982 (4.411) | 22.488 (5.181) | |
| - Range | 4.000 - 30.000 | 8.000 - 30.000 | 4.000 - 30.000 | |
| Traitement cholesterol | 0.389 | |||
| - 0 | 457 (84.2%) | 373 (86.1%) | 830 (85.0%) | |
| - 1 | 86 (15.8%) | 60 (13.9%) | 146 (15.0%) | |
| Traitement Diabete | 0.727 | |||
| - 0 | 506 (93.2%) | 401 (92.6%) | 907 (92.9%) | |
| - 1 | 37 (6.8%) | 32 (7.4%) | 69 (7.1%) | |
| Niveau d’étude | 0.413 | |||
| - N-Miss | 37 | 29 | 66 | |
| - études supérieurs | 193 (38.1%) | 147 (36.4%) | 340 (37.4%) | |
| - niveau études intermédiaires | 173 (34.2%) | 155 (38.4%) | 328 (36.0%) | |
| - niveau études mineurs | 140 (27.7%) | 102 (25.2%) | 242 (26.6%) |
## [1] "N = 1009"
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.19 | 1.04, 1.36 | 0.012 |
| age | 1.82 | 1.57, 2.13 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.95, 1.26 | 0.2 |
| age | 1.86 | 1.59, 2.17 | <0.001 |
| sexe | 1.69 | 1.28, 2.22 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.98 | 0.72, 1.32 | 0.9 |
| niveau études mineurs | 0.94 | 0.68, 1.31 | 0.7 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.05 | 0.91, 1.21 | 0.5 |
| age | 1.89 | 1.61, 2.22 | <0.001 |
| sexe | 1.79 | 1.35, 2.38 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.90 | 0.65, 1.23 | 0.5 |
| niveau études mineurs | 0.88 | 0.63, 1.25 | 0.5 |
| apoe.reg2 | 2.23 | 1.80, 2.79 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.05 | 0.91, 1.22 | 0.5 |
| age | 1.90 | 1.62, 2.25 | <0.001 |
| sexe | 1.71 | 1.28, 2.30 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.75 | 0.54, 1.04 | 0.089 |
| niveau études mineurs | 0.54 | 0.37, 0.78 | 0.001 |
| apoe.reg2 | 2.08 | 1.67, 2.60 | <0.001 |
| mmse | 0.90 | 0.87, 0.92 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.05 | 0.91, 1.22 | 0.5 |
| age | 1.90 | 1.61, 2.25 | <0.001 |
| sexe | 1.72 | 1.29, 2.31 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.75 | 0.54, 1.04 | 0.088 |
| niveau études mineurs | 0.53 | 0.36, 0.78 | 0.001 |
| apoe.reg2 | 2.08 | 1.67, 2.61 | <0.001 |
| mmse | 0.90 | 0.87, 0.92 | <0.001 |
| ch | 0.97 | 0.66, 1.43 | 0.9 |
| dia | 1.18 | 0.71, 1.97 | 0.5 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.02 | 0.88, 1.19 | 0.8 |
| age | 1.86 | 1.57, 2.21 | <0.001 |
| sexe | 1.64 | 1.22, 2.21 | 0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.57, 1.11 | 0.2 |
| niveau études mineurs | 0.58 | 0.39, 0.86 | 0.007 |
| apoe.reg2 | 2.05 | 1.64, 2.57 | <0.001 |
| mmse | 0.90 | 0.87, 0.93 | <0.001 |
| ch | 0.99 | 0.67, 1.46 | >0.9 |
| dia | 1.30 | 0.78, 2.20 | 0.3 |
| imc | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| cholesterol_total | 1.19 | 1.04, 1.36 | 0.012 | 1.10 | 0.95, 1.26 | 0.2 | 1.05 | 0.91, 1.21 | 0.5 | 1.05 | 0.91, 1.22 | 0.5 | 1.05 | 0.91, 1.22 | 0.5 | 1.02 | 0.88, 1.19 | 0.8 |
| age | 1.82 | 1.57, 2.13 | <0.001 | 1.86 | 1.59, 2.17 | <0.001 | 1.89 | 1.61, 2.22 | <0.001 | 1.90 | 1.62, 2.25 | <0.001 | 1.90 | 1.61, 2.25 | <0.001 | 1.86 | 1.57, 2.21 | <0.001 |
| sexe | 1.69 | 1.28, 2.22 | <0.001 | 1.79 | 1.35, 2.38 | <0.001 | 1.71 | 1.28, 2.30 | <0.001 | 1.72 | 1.29, 2.31 | <0.001 | 1.64 | 1.22, 2.21 | 0.001 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.98 | 0.72, 1.32 | 0.9 | 0.90 | 0.65, 1.23 | 0.5 | 0.75 | 0.54, 1.04 | 0.089 | 0.75 | 0.54, 1.04 | 0.088 | 0.80 | 0.57, 1.11 | 0.2 | |||
| niveau études mineurs | 0.94 | 0.68, 1.31 | 0.7 | 0.88 | 0.63, 1.25 | 0.5 | 0.54 | 0.37, 0.78 | 0.001 | 0.53 | 0.36, 0.78 | 0.001 | 0.58 | 0.39, 0.86 | 0.007 | |||
| apoe.reg2 | 2.23 | 1.80, 2.79 | <0.001 | 2.08 | 1.67, 2.60 | <0.001 | 2.08 | 1.67, 2.61 | <0.001 | 2.05 | 1.64, 2.57 | <0.001 | ||||||
| mmse | 0.90 | 0.87, 0.92 | <0.001 | 0.90 | 0.87, 0.92 | <0.001 | 0.90 | 0.87, 0.93 | <0.001 | |||||||||
| ch | 0.97 | 0.66, 1.43 | 0.9 | 0.99 | 0.67, 1.46 | >0.9 | ||||||||||||
| dia | 1.18 | 0.71, 1.97 | 0.5 | 1.30 | 0.78, 2.20 | 0.3 | ||||||||||||
| imc | 0.93 | 0.90, 0.96 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1038"
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.93 | 0.82, 1.05 | 0.2 |
| age | 1.80 | 1.56, 2.10 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.98 | 0.86, 1.12 | 0.8 |
| age | 1.86 | 1.60, 2.16 | <0.001 |
| sexe | 1.71 | 1.31, 2.23 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.94 | 0.70, 1.27 | 0.7 |
| niveau études mineurs | 0.88 | 0.63, 1.22 | 0.4 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.97 | 0.85, 1.11 | 0.6 |
| age | 1.88 | 1.61, 2.20 | <0.001 |
| sexe | 1.74 | 1.32, 2.28 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.88 | 0.65, 1.20 | 0.4 |
| niveau études mineurs | 0.84 | 0.60, 1.17 | 0.3 |
| apoe.reg2 | 2.19 | 1.77, 2.72 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.97 | 0.85, 1.12 | 0.7 |
| age | 1.90 | 1.62, 2.23 | <0.001 |
| sexe | 1.66 | 1.26, 2.20 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.76 | 0.55, 1.04 | 0.083 |
| niveau études mineurs | 0.49 | 0.33, 0.71 | <0.001 |
| apoe.reg2 | 2.07 | 1.66, 2.58 | <0.001 |
| mmse | 0.89 | 0.87, 0.92 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.96 | 0.83, 1.12 | 0.6 |
| age | 1.89 | 1.61, 2.23 | <0.001 |
| sexe | 1.66 | 1.26, 2.20 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.75 | 0.55, 1.04 | 0.082 |
| niveau études mineurs | 0.49 | 0.33, 0.71 | <0.001 |
| apoe.reg2 | 2.07 | 1.66, 2.58 | <0.001 |
| mmse | 0.89 | 0.87, 0.92 | <0.001 |
| ch | 1.05 | 0.72, 1.53 | 0.8 |
| dia | 1.06 | 0.61, 1.83 | 0.8 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 1.03 | 0.88, 1.21 | 0.7 |
| age | 1.84 | 1.56, 2.17 | <0.001 |
| sexe | 1.59 | 1.20, 2.11 | 0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.80 | 0.58, 1.11 | 0.2 |
| niveau études mineurs | 0.54 | 0.36, 0.79 | 0.002 |
| apoe.reg2 | 2.00 | 1.60, 2.50 | <0.001 |
| mmse | 0.89 | 0.87, 0.92 | <0.001 |
| ch | 1.10 | 0.75, 1.61 | 0.6 |
| dia | 1.08 | 0.62, 1.89 | 0.8 |
| imc | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| glucose_jeun | 0.93 | 0.82, 1.05 | 0.2 | 0.98 | 0.86, 1.12 | 0.8 | 0.97 | 0.85, 1.11 | 0.6 | 0.97 | 0.85, 1.12 | 0.7 | 0.96 | 0.83, 1.12 | 0.6 | 1.03 | 0.88, 1.21 | 0.7 |
| age | 1.80 | 1.56, 2.10 | <0.001 | 1.86 | 1.60, 2.16 | <0.001 | 1.88 | 1.61, 2.20 | <0.001 | 1.90 | 1.62, 2.23 | <0.001 | 1.89 | 1.61, 2.23 | <0.001 | 1.84 | 1.56, 2.17 | <0.001 |
| sexe | 1.71 | 1.31, 2.23 | <0.001 | 1.74 | 1.32, 2.28 | <0.001 | 1.66 | 1.26, 2.20 | <0.001 | 1.66 | 1.26, 2.20 | <0.001 | 1.59 | 1.20, 2.11 | 0.001 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.94 | 0.70, 1.27 | 0.7 | 0.88 | 0.65, 1.20 | 0.4 | 0.76 | 0.55, 1.04 | 0.083 | 0.75 | 0.55, 1.04 | 0.082 | 0.80 | 0.58, 1.11 | 0.2 | |||
| niveau études mineurs | 0.88 | 0.63, 1.22 | 0.4 | 0.84 | 0.60, 1.17 | 0.3 | 0.49 | 0.33, 0.71 | <0.001 | 0.49 | 0.33, 0.71 | <0.001 | 0.54 | 0.36, 0.79 | 0.002 | |||
| apoe.reg2 | 2.19 | 1.77, 2.72 | <0.001 | 2.07 | 1.66, 2.58 | <0.001 | 2.07 | 1.66, 2.58 | <0.001 | 2.00 | 1.60, 2.50 | <0.001 | ||||||
| mmse | 0.89 | 0.87, 0.92 | <0.001 | 0.89 | 0.87, 0.92 | <0.001 | 0.89 | 0.87, 0.92 | <0.001 | |||||||||
| ch | 1.05 | 0.72, 1.53 | 0.8 | 1.10 | 0.75, 1.61 | 0.6 | ||||||||||||
| dia | 1.06 | 0.61, 1.83 | 0.8 | 1.08 | 0.62, 1.89 | 0.8 | ||||||||||||
| imc | 0.93 | 0.90, 0.96 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1009"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.023 |
| age | 0.27 | 0.20, 0.34 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.04 | -0.03, 0.10 | 0.2 |
| age | 0.28 | 0.21, 0.34 | <0.001 |
| sexe | 0.22 | 0.10, 0.34 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 |
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.01 | -0.05, 0.08 | 0.6 |
| age | 0.27 | 0.21, 0.34 | <0.001 |
| sexe | 0.23 | 0.11, 0.35 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.03 | -0.10, 0.16 | 0.7 |
| niveau études mineurs | 0.01 | -0.13, 0.16 | 0.9 |
| apoe.reg2 | 0.34 | 0.25, 0.43 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.26 | 0.20, 0.32 | <0.001 |
| sexe | 0.20 | 0.09, 0.32 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.04 | -0.17, 0.09 | 0.5 |
| niveau études mineurs | -0.21 | -0.36, -0.06 | 0.006 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.01 | -0.05, 0.07 | 0.7 |
| age | 0.26 | 0.20, 0.33 | <0.001 |
| sexe | 0.20 | 0.08, 0.32 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.04 | -0.17, 0.09 | 0.6 |
| niveau études mineurs | -0.19 | -0.35, -0.04 | 0.013 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.05 | -0.06, -0.03 | <0.001 |
| ch | -0.04 | -0.20, 0.11 | 0.6 |
| dia | -0.16 | -0.37, 0.05 | 0.13 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.01 | -0.05, 0.07 | 0.7 |
| age | 0.26 | 0.19, 0.32 | <0.001 |
| sexe | 0.18 | 0.07, 0.30 | 0.002 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.15, 0.11 | 0.7 |
| niveau études mineurs | -0.18 | -0.33, -0.03 | 0.022 |
| apoe.reg2 | 0.28 | 0.20, 0.37 | <0.001 |
| mmse | -0.05 | -0.06, -0.03 | <0.001 |
| ch | -0.04 | -0.20, 0.12 | 0.6 |
| dia | -0.15 | -0.36, 0.06 | 0.2 |
| imc | -0.01 | -0.02, 0.00 | 0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.023 | 0.04 | -0.03, 0.10 | 0.2 | 0.01 | -0.05, 0.08 | 0.6 | 0.02 | -0.04, 0.08 | 0.5 | 0.01 | -0.05, 0.07 | 0.7 | 0.01 | -0.05, 0.07 | 0.7 |
| age | 0.27 | 0.20, 0.34 | <0.001 | 0.28 | 0.21, 0.34 | <0.001 | 0.27 | 0.21, 0.34 | <0.001 | 0.26 | 0.20, 0.32 | <0.001 | 0.26 | 0.20, 0.33 | <0.001 | 0.26 | 0.19, 0.32 | <0.001 |
| sexe | 0.22 | 0.10, 0.34 | <0.001 | 0.23 | 0.11, 0.35 | <0.001 | 0.20 | 0.09, 0.32 | <0.001 | 0.20 | 0.08, 0.32 | <0.001 | 0.18 | 0.07, 0.30 | 0.002 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 | 0.03 | -0.10, 0.16 | 0.7 | -0.04 | -0.17, 0.09 | 0.5 | -0.04 | -0.17, 0.09 | 0.6 | -0.02 | -0.15, 0.11 | 0.7 | |||
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 | 0.01 | -0.13, 0.16 | 0.9 | -0.21 | -0.36, -0.06 | 0.006 | -0.19 | -0.35, -0.04 | 0.013 | -0.18 | -0.33, -0.03 | 0.022 | |||
| apoe.reg2 | 0.34 | 0.25, 0.43 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | 0.28 | 0.20, 0.37 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.03 | <0.001 | -0.05 | -0.06, -0.03 | <0.001 | |||||||||
| ch | -0.04 | -0.20, 0.11 | 0.6 | -0.04 | -0.20, 0.12 | 0.6 | ||||||||||||
| dia | -0.16 | -0.37, 0.05 | 0.13 | -0.15 | -0.36, 0.06 | 0.2 | ||||||||||||
| imc | -0.01 | -0.02, 0.00 | 0.001 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1038"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.046 |
| age | 0.27 | 0.21, 0.34 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.28 | 0.22, 0.35 | <0.001 |
| sexe | 0.20 | 0.08, 0.32 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.06 | -0.07, 0.20 | 0.3 |
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.01 | 0.14 |
| age | 0.28 | 0.22, 0.34 | <0.001 |
| sexe | 0.20 | 0.08, 0.31 | <0.001 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.04 | -0.09, 0.17 | 0.5 |
| niveau études mineurs | 0.01 | -0.13, 0.16 | 0.8 |
| apoe.reg2 | 0.33 | 0.25, 0.42 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.04 | -0.10, 0.02 | 0.2 |
| age | 0.27 | 0.21, 0.33 | <0.001 |
| sexe | 0.17 | 0.06, 0.28 | 0.002 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.15, 0.10 | 0.7 |
| niveau études mineurs | -0.22 | -0.37, -0.07 | 0.004 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.02 | -0.08, 0.04 | 0.5 |
| age | 0.27 | 0.21, 0.33 | <0.001 |
| sexe | 0.17 | 0.06, 0.28 | 0.003 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.02 | -0.15, 0.11 | 0.8 |
| niveau études mineurs | -0.21 | -0.36, -0.06 | 0.006 |
| apoe.reg2 | 0.29 | 0.20, 0.37 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | -0.01 | -0.16, 0.14 | >0.9 |
| dia | -0.16 | -0.38, 0.06 | 0.2 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.01 | -0.07, 0.05 | 0.7 |
| age | 0.26 | 0.20, 0.32 | <0.001 |
| sexe | 0.16 | 0.05, 0.27 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.01 | -0.13, 0.12 | >0.9 |
| niveau études mineurs | -0.19 | -0.34, -0.04 | 0.011 |
| apoe.reg2 | 0.28 | 0.20, 0.36 | <0.001 |
| mmse | -0.05 | -0.06, -0.04 | <0.001 |
| ch | 0.00 | -0.15, 0.15 | >0.9 |
| dia | -0.16 | -0.38, 0.07 | 0.2 |
| imc | -0.01 | -0.02, 0.00 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.046 | -0.04 | -0.10, 0.02 | 0.2 | -0.04 | -0.10, 0.01 | 0.14 | -0.04 | -0.10, 0.02 | 0.2 | -0.02 | -0.08, 0.04 | 0.5 | -0.01 | -0.07, 0.05 | 0.7 |
| age | 0.27 | 0.21, 0.34 | <0.001 | 0.28 | 0.22, 0.35 | <0.001 | 0.28 | 0.22, 0.34 | <0.001 | 0.27 | 0.21, 0.33 | <0.001 | 0.27 | 0.21, 0.33 | <0.001 | 0.26 | 0.20, 0.32 | <0.001 |
| sexe | 0.20 | 0.08, 0.32 | <0.001 | 0.20 | 0.08, 0.31 | <0.001 | 0.17 | 0.06, 0.28 | 0.002 | 0.17 | 0.06, 0.28 | 0.003 | 0.16 | 0.05, 0.27 | 0.005 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.06 | -0.07, 0.20 | 0.3 | 0.04 | -0.09, 0.17 | 0.5 | -0.02 | -0.15, 0.10 | 0.7 | -0.02 | -0.15, 0.11 | 0.8 | -0.01 | -0.13, 0.12 | >0.9 | |||
| niveau études mineurs | 0.03 | -0.12, 0.18 | 0.7 | 0.01 | -0.13, 0.16 | 0.8 | -0.22 | -0.37, -0.07 | 0.004 | -0.21 | -0.36, -0.06 | 0.006 | -0.19 | -0.34, -0.04 | 0.011 | |||
| apoe.reg2 | 0.33 | 0.25, 0.42 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | 0.29 | 0.20, 0.37 | <0.001 | 0.28 | 0.20, 0.36 | <0.001 | ||||||
| mmse | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | -0.05 | -0.06, -0.04 | <0.001 | |||||||||
| ch | -0.01 | -0.16, 0.14 | >0.9 | 0.00 | -0.15, 0.15 | >0.9 | ||||||||||||
| dia | -0.16 | -0.38, 0.06 | 0.2 | -0.16 | -0.38, 0.07 | 0.2 | ||||||||||||
| imc | -0.01 | -0.02, 0.00 | <0.001 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
| ptau elevé (N=495) | ptau normal (N=481) | Total (N=976) | p value | |
|---|---|---|---|---|
| Age | < 0.001 | |||
| - Mean (SD) | 71.531 (8.008) | 67.744 (9.346) | 69.665 (8.893) | |
| - Range | 50.000 - 89.000 | 42.000 - 88.000 | 42.000 - 89.000 | |
| Sexe | 0.006 | |||
| - Femme | 290 (58.6%) | 240 (49.9%) | 530 (54.3%) | |
| - Homme | 205 (41.4%) | 241 (50.1%) | 446 (45.7%) | |
| Glucose | 0.318 | |||
| - Mean (SD) | 5.701 (1.533) | 5.809 (1.834) | 5.754 (1.688) | |
| - Range | 0.920 - 20.900 | 0.720 - 24.500 | 0.720 - 24.500 | |
| Triglycerides | 0.146 | |||
| - Mean (SD) | 0.936 (0.333) | 0.967 (0.345) | 0.951 (0.339) | |
| - Range | 0.340 - 1.970 | 0.150 - 1.970 | 0.150 - 1.970 | |
| Cholesterol | 0.019 | |||
| - Mean (SD) | 2.155 (0.517) | 2.078 (0.501) | 2.117 (0.510) | |
| - Range | 1.030 - 6.640 | 0.820 - 5.900 | 0.820 - 6.640 | |
| Cholesterol hdl | < 0.001 | |||
| - Mean (SD) | 0.611 (0.161) | 0.573 (0.157) | 0.593 (0.160) | |
| - Range | 0.210 - 1.100 | 0.240 - 1.590 | 0.210 - 1.590 | |
| Cholesterol ldl | 0.027 | |||
| - Mean (SD) | 1.348 (0.414) | 1.292 (0.375) | 1.321 (0.396) | |
| - Range | 0.360 - 2.970 | 0.200 - 2.380 | 0.200 - 2.970 | |
| Présence E4 | < 0.001 | |||
| - 0 | 219 (44.2%) | 321 (66.7%) | 540 (55.3%) | |
| - 1 | 213 (43.0%) | 139 (28.9%) | 352 (36.1%) | |
| - 2 | 63 (12.7%) | 21 (4.4%) | 84 (8.6%) | |
| MMSE | < 0.001 | |||
| - Mean (SD) | 21.477 (5.299) | 23.528 (4.846) | 22.488 (5.181) | |
| - Range | 6.000 - 30.000 | 4.000 - 30.000 | 4.000 - 30.000 | |
| Traitement cholesterol | 0.153 | |||
| - 0 | 413 (83.4%) | 417 (86.7%) | 830 (85.0%) | |
| - 1 | 82 (16.6%) | 64 (13.3%) | 146 (15.0%) | |
| Traitement Diabete | 0.081 | |||
| - 0 | 467 (94.3%) | 440 (91.5%) | 907 (92.9%) | |
| - 1 | 28 (5.7%) | 41 (8.5%) | 69 (7.1%) | |
| Niveau d’étude | 0.734 | |||
| - N-Miss | 33 | 33 | 66 | |
| - études supérieurs | 169 (36.6%) | 171 (38.2%) | 340 (37.4%) | |
| - niveau études intermédiaires | 165 (35.7%) | 163 (36.4%) | 328 (36.0%) | |
| - niveau études mineurs | 128 (27.7%) | 114 (25.4%) | 242 (26.6%) |
## [1] "N = 1009"
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.20 | 1.06, 1.38 | 0.006 |
| age | 1.72 | 1.48, 2.00 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.14 | 1.00, 1.32 | 0.060 |
| age | 1.75 | 1.50, 2.04 | <0.001 |
| sexe | 1.42 | 1.09, 1.87 | 0.010 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.20 | 0.89, 1.62 | 0.2 |
| niveau études mineurs | 1.09 | 0.79, 1.51 | 0.6 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.95, 1.27 | 0.2 |
| age | 1.77 | 1.52, 2.07 | <0.001 |
| sexe | 1.49 | 1.13, 1.97 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.13 | 0.83, 1.54 | 0.4 |
| niveau études mineurs | 1.04 | 0.75, 1.46 | 0.8 |
| apoe.reg2 | 2.01 | 1.64, 2.49 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.96, 1.27 | 0.2 |
| age | 1.77 | 1.51, 2.08 | <0.001 |
| sexe | 1.43 | 1.08, 1.90 | 0.013 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.74, 1.38 | >0.9 |
| niveau études mineurs | 0.74 | 0.51, 1.07 | 0.11 |
| apoe.reg2 | 1.90 | 1.54, 2.35 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.10 | 0.95, 1.28 | 0.2 |
| age | 1.76 | 1.50, 2.07 | <0.001 |
| sexe | 1.41 | 1.06, 1.87 | 0.017 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.74, 1.39 | >0.9 |
| niveau études mineurs | 0.75 | 0.52, 1.09 | 0.13 |
| apoe.reg2 | 1.89 | 1.53, 2.34 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.18 | 0.81, 1.73 | 0.4 |
| dia | 0.75 | 0.45, 1.24 | 0.3 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 1.07 | 0.93, 1.24 | 0.3 |
| age | 1.72 | 1.46, 2.03 | <0.001 |
| sexe | 1.34 | 1.01, 1.79 | 0.044 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.07 | 0.78, 1.48 | 0.7 |
| niveau études mineurs | 0.83 | 0.57, 1.20 | 0.3 |
| apoe.reg2 | 1.86 | 1.50, 2.31 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.21 | 0.82, 1.77 | 0.3 |
| dia | 0.82 | 0.49, 1.36 | 0.4 |
| imc | 0.94 | 0.91, 0.97 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| cholesterol_total | 1.20 | 1.06, 1.38 | 0.006 | 1.14 | 1.00, 1.32 | 0.060 | 1.10 | 0.95, 1.27 | 0.2 | 1.10 | 0.96, 1.27 | 0.2 | 1.10 | 0.95, 1.28 | 0.2 | 1.07 | 0.93, 1.24 | 0.3 |
| age | 1.72 | 1.48, 2.00 | <0.001 | 1.75 | 1.50, 2.04 | <0.001 | 1.77 | 1.52, 2.07 | <0.001 | 1.77 | 1.51, 2.08 | <0.001 | 1.76 | 1.50, 2.07 | <0.001 | 1.72 | 1.46, 2.03 | <0.001 |
| sexe | 1.42 | 1.09, 1.87 | 0.010 | 1.49 | 1.13, 1.97 | 0.005 | 1.43 | 1.08, 1.90 | 0.013 | 1.41 | 1.06, 1.87 | 0.017 | 1.34 | 1.01, 1.79 | 0.044 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.20 | 0.89, 1.62 | 0.2 | 1.13 | 0.83, 1.54 | 0.4 | 1.01 | 0.74, 1.38 | >0.9 | 1.01 | 0.74, 1.39 | >0.9 | 1.07 | 0.78, 1.48 | 0.7 | |||
| niveau études mineurs | 1.09 | 0.79, 1.51 | 0.6 | 1.04 | 0.75, 1.46 | 0.8 | 0.74 | 0.51, 1.07 | 0.11 | 0.75 | 0.52, 1.09 | 0.13 | 0.83 | 0.57, 1.20 | 0.3 | |||
| apoe.reg2 | 2.01 | 1.64, 2.49 | <0.001 | 1.90 | 1.54, 2.35 | <0.001 | 1.89 | 1.53, 2.34 | <0.001 | 1.86 | 1.50, 2.31 | <0.001 | ||||||
| mmse | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | |||||||||
| ch | 1.18 | 0.81, 1.73 | 0.4 | 1.21 | 0.82, 1.77 | 0.3 | ||||||||||||
| dia | 0.75 | 0.45, 1.24 | 0.3 | 0.82 | 0.49, 1.36 | 0.4 | ||||||||||||
| imc | 0.94 | 0.91, 0.97 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1038"
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.86 | 0.75, 0.98 | 0.023 |
| age | 1.71 | 1.48, 1.98 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.89 | 0.78, 1.02 | 0.093 |
| age | 1.75 | 1.51, 2.04 | <0.001 |
| sexe | 1.45 | 1.12, 1.88 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.17 | 0.87, 1.57 | 0.3 |
| niveau études mineurs | 1.06 | 0.77, 1.47 | 0.7 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.88 | 0.77, 1.00 | 0.062 |
| age | 1.77 | 1.52, 2.07 | <0.001 |
| sexe | 1.46 | 1.12, 1.91 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.11 | 0.82, 1.51 | 0.5 |
| niveau études mineurs | 1.02 | 0.74, 1.43 | 0.9 |
| apoe.reg2 | 2.04 | 1.66, 2.51 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.88 | 0.77, 1.01 | 0.066 |
| age | 1.77 | 1.52, 2.07 | <0.001 |
| sexe | 1.41 | 1.07, 1.84 | 0.013 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.01 | 0.75, 1.38 | >0.9 |
| niveau études mineurs | 0.72 | 0.50, 1.03 | 0.077 |
| apoe.reg2 | 1.94 | 1.58, 2.40 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.90 | 0.78, 1.05 | 0.2 |
| age | 1.75 | 1.50, 2.05 | <0.001 |
| sexe | 1.40 | 1.07, 1.84 | 0.014 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.02 | 0.75, 1.38 | >0.9 |
| niveau études mineurs | 0.72 | 0.50, 1.03 | 0.076 |
| apoe.reg2 | 1.92 | 1.56, 2.38 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.25 | 0.87, 1.81 | 0.2 |
| dia | 0.77 | 0.45, 1.32 | 0.3 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
## Warning: glm.fit: des probabilités ont été ajustées numériquement à 0 ou 1
| Characteristic | OR1 | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | 0.95 | 0.82, 1.11 | 0.5 |
| age | 1.70 | 1.45, 2.00 | <0.001 |
| sexe | 1.34 | 1.02, 1.77 | 0.034 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 1.07 | 0.79, 1.47 | 0.7 |
| niveau études mineurs | 0.79 | 0.55, 1.15 | 0.2 |
| apoe.reg2 | 1.86 | 1.51, 2.31 | <0.001 |
| mmse | 0.93 | 0.90, 0.96 | <0.001 |
| ch | 1.30 | 0.90, 1.89 | 0.2 |
| dia | 0.79 | 0.46, 1.36 | 0.4 |
| imc | 0.94 | 0.91, 0.97 | <0.001 |
| 1 OR = Odds Ratio, CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | OR1 | 95% CI1 | p-value | |
| glucose_jeun | 0.86 | 0.75, 0.98 | 0.023 | 0.89 | 0.78, 1.02 | 0.093 | 0.88 | 0.77, 1.00 | 0.062 | 0.88 | 0.77, 1.01 | 0.066 | 0.90 | 0.78, 1.05 | 0.2 | 0.95 | 0.82, 1.11 | 0.5 |
| age | 1.71 | 1.48, 1.98 | <0.001 | 1.75 | 1.51, 2.04 | <0.001 | 1.77 | 1.52, 2.07 | <0.001 | 1.77 | 1.52, 2.07 | <0.001 | 1.75 | 1.50, 2.05 | <0.001 | 1.70 | 1.45, 2.00 | <0.001 |
| sexe | 1.45 | 1.12, 1.88 | 0.005 | 1.46 | 1.12, 1.91 | 0.005 | 1.41 | 1.07, 1.84 | 0.013 | 1.40 | 1.07, 1.84 | 0.014 | 1.34 | 1.02, 1.77 | 0.034 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 1.17 | 0.87, 1.57 | 0.3 | 1.11 | 0.82, 1.51 | 0.5 | 1.01 | 0.75, 1.38 | >0.9 | 1.02 | 0.75, 1.38 | >0.9 | 1.07 | 0.79, 1.47 | 0.7 | |||
| niveau études mineurs | 1.06 | 0.77, 1.47 | 0.7 | 1.02 | 0.74, 1.43 | 0.9 | 0.72 | 0.50, 1.03 | 0.077 | 0.72 | 0.50, 1.03 | 0.076 | 0.79 | 0.55, 1.15 | 0.2 | |||
| apoe.reg2 | 2.04 | 1.66, 2.51 | <0.001 | 1.94 | 1.58, 2.40 | <0.001 | 1.92 | 1.56, 2.38 | <0.001 | 1.86 | 1.51, 2.31 | <0.001 | ||||||
| mmse | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | 0.93 | 0.90, 0.96 | <0.001 | |||||||||
| ch | 1.25 | 0.87, 1.81 | 0.2 | 1.30 | 0.90, 1.89 | 0.2 | ||||||||||||
| dia | 0.77 | 0.45, 1.32 | 0.3 | 0.79 | 0.46, 1.36 | 0.4 | ||||||||||||
| imc | 0.94 | 0.91, 0.97 | <0.001 | |||||||||||||||
| 1 OR = Odds Ratio, CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1009"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.018 |
| age | 0.26 | 0.19, 0.33 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.05 | -0.02, 0.11 | 0.14 |
| age | 0.26 | 0.20, 0.33 | <0.001 |
| sexe | 0.18 | 0.05, 0.30 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 |
| niveau études mineurs | 0.06 | -0.09, 0.21 | 0.5 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.09 | 0.4 |
| age | 0.26 | 0.19, 0.33 | <0.001 |
| sexe | 0.19 | 0.07, 0.31 | 0.002 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.02 | -0.11, 0.16 | 0.7 |
| niveau études mineurs | 0.03 | -0.11, 0.18 | 0.7 |
| apoe.reg2 | 0.35 | 0.26, 0.44 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.03 | -0.03, 0.09 | 0.4 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.17 | 0.05, 0.29 | 0.005 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.03 | -0.16, 0.10 | 0.7 |
| niveau études mineurs | -0.13 | -0.29, 0.02 | 0.087 |
| apoe.reg2 | 0.32 | 0.23, 0.40 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.16 | 0.04, 0.28 | 0.008 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.03 | -0.16, 0.11 | 0.7 |
| niveau études mineurs | -0.12 | -0.28, 0.04 | 0.13 |
| apoe.reg2 | 0.31 | 0.23, 0.40 | <0.001 |
| mmse | -0.03 | -0.05, -0.02 | <0.001 |
| ch | 0.01 | -0.15, 0.17 | >0.9 |
| dia | -0.16 | -0.37, 0.06 | 0.2 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| cholesterol_total | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.15 | 0.03, 0.27 | 0.014 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | -0.01 | -0.15, 0.12 | 0.8 |
| niveau études mineurs | -0.11 | -0.26, 0.05 | 0.2 |
| apoe.reg2 | 0.31 | 0.22, 0.39 | <0.001 |
| mmse | -0.03 | -0.05, -0.02 | <0.001 |
| ch | 0.01 | -0.15, 0.17 | >0.9 |
| dia | -0.14 | -0.36, 0.07 | 0.2 |
| imc | -0.01 | -0.01, 0.00 | 0.009 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| cholesterol_total | 0.07 | 0.01, 0.13 | 0.018 | 0.05 | -0.02, 0.11 | 0.14 | 0.02 | -0.04, 0.09 | 0.4 | 0.03 | -0.03, 0.09 | 0.4 | 0.02 | -0.04, 0.08 | 0.5 | 0.02 | -0.04, 0.08 | 0.5 |
| age | 0.26 | 0.19, 0.33 | <0.001 | 0.26 | 0.20, 0.33 | <0.001 | 0.26 | 0.19, 0.33 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.18 | 0.05, 0.30 | 0.005 | 0.19 | 0.07, 0.31 | 0.002 | 0.17 | 0.05, 0.29 | 0.005 | 0.16 | 0.04, 0.28 | 0.008 | 0.15 | 0.03, 0.27 | 0.014 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.06 | -0.08, 0.20 | 0.4 | 0.02 | -0.11, 0.16 | 0.7 | -0.03 | -0.16, 0.10 | 0.7 | -0.03 | -0.16, 0.11 | 0.7 | -0.01 | -0.15, 0.12 | 0.8 | |||
| niveau études mineurs | 0.06 | -0.09, 0.21 | 0.5 | 0.03 | -0.11, 0.18 | 0.7 | -0.13 | -0.29, 0.02 | 0.087 | -0.12 | -0.28, 0.04 | 0.13 | -0.11 | -0.26, 0.05 | 0.2 | |||
| apoe.reg2 | 0.35 | 0.26, 0.44 | <0.001 | 0.32 | 0.23, 0.40 | <0.001 | 0.31 | 0.23, 0.40 | <0.001 | 0.31 | 0.22, 0.39 | <0.001 | ||||||
| mmse | -0.04 | -0.05, -0.02 | <0.001 | -0.03 | -0.05, -0.02 | <0.001 | -0.03 | -0.05, -0.02 | <0.001 | |||||||||
| ch | 0.01 | -0.15, 0.17 | >0.9 | 0.01 | -0.15, 0.17 | >0.9 | ||||||||||||
| dia | -0.16 | -0.37, 0.06 | 0.2 | -0.14 | -0.36, 0.07 | 0.2 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.009 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
## [1] "N = 1038"
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.039 |
| age | 0.26 | 0.20, 0.32 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.10, 0.01 | 0.13 |
| age | 0.27 | 0.20, 0.33 | <0.001 |
| sexe | 0.16 | 0.04, 0.28 | 0.008 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.08 | -0.06, 0.21 | 0.3 |
| niveau études mineurs | 0.06 | -0.08, 0.21 | 0.4 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.11, 0.01 | 0.087 |
| age | 0.26 | 0.20, 0.33 | <0.001 |
| sexe | 0.16 | 0.04, 0.27 | 0.008 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.05 | -0.08, 0.18 | 0.4 |
| niveau études mineurs | 0.05 | -0.10, 0.19 | 0.5 |
| apoe.reg2 | 0.34 | 0.25, 0.42 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.05 | -0.10, 0.01 | 0.10 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.14 | 0.02, 0.25 | 0.017 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.00 | -0.13, 0.13 | >0.9 |
| niveau études mineurs | -0.13 | -0.28, 0.02 | 0.094 |
| apoe.reg2 | 0.30 | 0.22, 0.39 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.09, 0.03 | 0.3 |
| age | 0.25 | 0.19, 0.32 | <0.001 |
| sexe | 0.14 | 0.02, 0.25 | 0.018 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.01 | -0.12, 0.13 | >0.9 |
| niveau études mineurs | -0.13 | -0.28, 0.03 | 0.11 |
| apoe.reg2 | 0.30 | 0.21, 0.39 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| ch | 0.04 | -0.11, 0.19 | 0.6 |
| dia | -0.14 | -0.37, 0.09 | 0.2 |
| 1 CI = Confidence Interval | |||
| Characteristic | Beta | 95% CI1 | p-value |
|---|---|---|---|
| glucose_jeun | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.13 | 0.01, 0.24 | 0.030 |
| niveau_etude_reg | |||
| études supérieurs | — | — | |
| niveau études intermédiaires | 0.02 | -0.11, 0.15 | 0.8 |
| niveau études mineurs | -0.11 | -0.26, 0.04 | 0.2 |
| apoe.reg2 | 0.29 | 0.21, 0.38 | <0.001 |
| mmse | -0.04 | -0.05, -0.02 | <0.001 |
| ch | 0.04 | -0.11, 0.20 | 0.6 |
| dia | -0.14 | -0.36, 0.09 | 0.2 |
| imc | -0.01 | -0.01, 0.00 | 0.005 |
| 1 CI = Confidence Interval | |||
| Characteristic | Modèle 1 | Modèle 2 | Modèle 3 | Modèle 4 | Modèle 5 | Modèle 6 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | Beta | 95% CI1 | p-value | |
| glucose_jeun | -0.06 | -0.12, 0.00 | 0.039 | -0.05 | -0.10, 0.01 | 0.13 | -0.05 | -0.11, 0.01 | 0.087 | -0.05 | -0.10, 0.01 | 0.10 | -0.03 | -0.09, 0.03 | 0.3 | -0.03 | -0.09, 0.04 | 0.4 |
| age | 0.26 | 0.20, 0.32 | <0.001 | 0.27 | 0.20, 0.33 | <0.001 | 0.26 | 0.20, 0.33 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.19, 0.32 | <0.001 | 0.25 | 0.18, 0.31 | <0.001 |
| sexe | 0.16 | 0.04, 0.28 | 0.008 | 0.16 | 0.04, 0.27 | 0.008 | 0.14 | 0.02, 0.25 | 0.017 | 0.14 | 0.02, 0.25 | 0.018 | 0.13 | 0.01, 0.24 | 0.030 | |||
| niveau_etude_reg | ||||||||||||||||||
| études supérieurs | — | — | — | — | — | — | — | — | — | — | ||||||||
| niveau études intermédiaires | 0.08 | -0.06, 0.21 | 0.3 | 0.05 | -0.08, 0.18 | 0.4 | 0.00 | -0.13, 0.13 | >0.9 | 0.01 | -0.12, 0.13 | >0.9 | 0.02 | -0.11, 0.15 | 0.8 | |||
| niveau études mineurs | 0.06 | -0.08, 0.21 | 0.4 | 0.05 | -0.10, 0.19 | 0.5 | -0.13 | -0.28, 0.02 | 0.094 | -0.13 | -0.28, 0.03 | 0.11 | -0.11 | -0.26, 0.04 | 0.2 | |||
| apoe.reg2 | 0.34 | 0.25, 0.42 | <0.001 | 0.30 | 0.22, 0.39 | <0.001 | 0.30 | 0.21, 0.39 | <0.001 | 0.29 | 0.21, 0.38 | <0.001 | ||||||
| mmse | -0.04 | -0.05, -0.02 | <0.001 | -0.04 | -0.05, -0.02 | <0.001 | -0.04 | -0.05, -0.02 | <0.001 | |||||||||
| ch | 0.04 | -0.11, 0.19 | 0.6 | 0.04 | -0.11, 0.20 | 0.6 | ||||||||||||
| dia | -0.14 | -0.37, 0.09 | 0.2 | -0.14 | -0.36, 0.09 | 0.2 | ||||||||||||
| imc | -0.01 | -0.01, 0.00 | 0.005 | |||||||||||||||
| 1 CI = Confidence Interval | ||||||||||||||||||
# Export BDD avec scale variable
"data_export = data.frame(abeta42_continu = data2$abeta42_,
abeta_42_modalite = data2$abeta42t2,
tau_continu = data2$tau_,
tau_modalite = data2$taut2,
glucose = data2$glucose_jeun,
glucose_std = scale(data2$glucose_jeun),
triglycerides = data2$triglycerides,
triglycerides_std = scale(data2$triglycerides),
cholesterol_total = data2$cholesterol_total,
cholesterol_total_std = scale(data2$cholesterol_total),
cholesterol_hdl = data2$cholesterol_hdl,
cholesterol_hdl.std = scale(data2$cholesterol_hdl),
cholesterol_ldl = data2$cholesterol_ldl,
cholesterol_ldl.std = scale(data2$cholesterol_ldl),
education = data2$niveau_etude_reg,
age = data2$age,
sexe = data2$sexe_reg,
apoe = data2$apoe,
traitement_chol = data2$ch,
traitement_dia = data2$dia,
mmse = data2$mmse,
imc = data2$imc
)"
## [1] "data_export = data.frame(abeta42_continu = data2$abeta42_,\n abeta_42_modalite = data2$abeta42t2,\n tau_continu = data2$tau_,\n tau_modalite = data2$taut2,\n glucose = data2$glucose_jeun,\n glucose_std = scale(data2$glucose_jeun),\n triglycerides = data2$triglycerides,\n triglycerides_std = scale(data2$triglycerides),\n cholesterol_total = data2$cholesterol_total,\n cholesterol_total_std = scale(data2$cholesterol_total),\n cholesterol_hdl = data2$cholesterol_hdl,\n cholesterol_hdl.std = scale(data2$cholesterol_hdl),\n cholesterol_ldl = data2$cholesterol_ldl,\n cholesterol_ldl.std = scale(data2$cholesterol_ldl),\n education = data2$niveau_etude_reg,\n age = data2$age,\n sexe = data2$sexe_reg,\n apoe = data2$apoe,\n traitement_chol = data2$ch,\n traitement_dia = data2$dia,\n mmse = data2$mmse,\n imc = data2$imc\n )"
#write.csv(data_export,"//172.27.137.244/g_boilay/alternance/export/data_export.csv")